Cardene and Phenytoin
Determining the interaction of Cardene and Phenytoin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using niCARdipine together with phenytoin may increase the effects of phenytoin. You should notify your doctor if you have symptoms such as drowsiness, visual disturbances, seizures, changes in behavior, nausea, or poor muscle coordination. You may need dose adjustments or special tests in order to safely use both medications together. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Diltiazem and verapamil may increase plasma phenytoin levels. Toxicity has been reported. The proposed mechanism is inhibition of CYP450 3A4 metabolism. In addition, phenytoin may significantly decrease calcium channel blocker (CCB) serum levels by inducing first-pass metabolism and the systemic clearance. Other hydantoins may participate in these interactions as well.
MANAGEMENT: Close clinical and laboratory observation for evidence of altered effect of both drugs is recommended if a CCB and a hydantoin must be used together. Patients should be advised to notify their physician if they experience symptoms of phenytoin toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia) or loss of effect of their CCB.
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Generic Name: nicardipine
Brand name: Cardene IV, Cardene SR, Cardene
Synonyms: Cardene (Oral)
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cardene-Phenytoin Capsules
- Cardene-Phenytoin Chewable Tablets
- Cardene-Phenytoin Extended-Release Capsules
- Cardene-Phenytoin Infatabs
- Cardene-Phenytoin injection
- Cardene-Phenytoin Intravenous
- Phenytoin-Cardene Injection
- Phenytoin-Cardene Intravenous
- Phenytoin-Cardene IV
- Phenytoin-Cardene SR
- Phenytoin-Cardioquin
- Phenytoin-Cardioxane Injection