Cardene Injection and Rapaflo
Determining the interaction of Cardene Injection and Rapaflo and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using silodosin together with niCARdipine is not recommended. Combining these medications may significantly increase the blood levels and effects of silodosin. This may cause blood pressure to fall excessively and heart rate to increase, especially when you rise from a sitting or lying position. The risk of other side effects such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity) may also increase. Let your doctor know if you develop these symptoms while using silodosin and they do not go away on their own or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medication affects you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inhibitors of the P-glycoprotein (P-gp) efflux transporter may significantly increase the oral bioavailability of silodosin, which has been shown in vitro to be a substrate of P-gp. In a pharmacokinetic study, administration of a single 8 mg dose of silodosin with the potent CYP450 3A4/P-gp inhibitor ketoconazole (400 mg) resulted in a 3.8-fold increase in silodosin peak plasma concentration (Cmax) and a 3.2-fold increase in systemic exposure (AUC). However, the extent to which P-gp inhibition actually contributes to the overall interaction is unknown.
MANAGEMENT: Concomitant use of silodosin with potent P-gp inhibitors such as cyclosporine is not recommended.
- "Product Information. Rapaflo (silodosin)." Watson Pharmaceuticals, Corona, CA.
Generic Name: nicardipine
Brand name: Cardene IV, Cardene SR, Cardene
Synonyms: Cardene IV
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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