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Cardioquin and Dilantin-30

Determining the interaction of Cardioquin and Dilantin-30 and the possibility of their joint administration.

Check result:

Cardioquin <> Dilantin-30

Relevance: 21.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenytoin together with quiNIDine may decrease the effects of quiNIDine. Contact your doctor if you experience increased irregular heartbeats or worsening of your symptoms. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Hydantoins may increase the CYP450 hepatic metabolism of quinidine. Serum quinidine levels and quinidine effectiveness may be decreased.

MANAGEMENT: Quinidine levels and effectiveness should be monitored frequently after a hydantoin is added to or deleted from the patient's regimen. An increase in quinidine dosage may be required. Patients should be advised to notify their physician if they experience increased irregular heartbeats or worsening of their symptoms.

References

Urbano AM "Phenytoin-quinidine interactions in a patient with recurrent ventricular tachyarrhythmias." N Engl J Med 308 (1983): 225
Farringer JA, Beach CL, Robinson CA, Wooding-Scott R, Slaughter RL, Clementi WA "Quinidine and 3-hydroxyquinidine levels during initiation of anticonvulsant therapy after chronic anticonvulsant administration." Drug Intell Clin Pharm 19 (1985): 461
Data JL, Wilkinson GR, Nies AS "Interaction of quinidine with anticonvulsant drugs." N Engl J Med 294 (1976): 699-702

Cardioquin

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Cardioquin?

Dilantin-30

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Dilantin

What is Dilantin-30?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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