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Cardioquin and Disopyramide Sustained-Release Capsules

Determining the interaction of Cardioquin and Disopyramide Sustained-Release Capsules and the possibility of their joint administration.

Check result:

Cardioquin <> Disopyramide Sustained-Release Capsules

Relevance: 21.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using disopyramide together with quiNIDine may alter the effects of both medications. This could affect the rhythm of your heart. Contact your doctor if you experience dizziness, weakness, headache, difficulty breathing, and an irregular heartbeat. This may also cause other side effects such as dry mouth, blurred vision, and urinary retention. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Quinidine may slightly increase serum disopyramide levels. Disopyramide may decrease serum quinidine levels. The mechanism is unknown. In addition, QT interval prolongation and excessive QRS complex widening may occur with this combination. The risk of arrhythmias, including ventricular tachycardia, fibrillation, and torsades de pointes may be increased.

MANAGEMENT: Patients should be monitored for clinical, electrocardiographic and laboratory evidence of efficacy and toxicity. Patients should be advised to seek medical help if they experience syncope, palpitations, or irregular heartbeats, and to notify their physician if they excessive anticholinergic effects (e.g., dry mouth, blurred vision, urinary retention).

References

Zilberter YI, Starmer CF, Grant AO "Open Na+ channel blockade: multiple rest states revealed by channel interactions with disopyramide and quinidine." Am J Physiol 266 (1994): h2007-17
Baker BJ, Gammill J, Massengill J, Schubert E, Karin A, Doherty JE "Concurrent use of quinidine and disopyramide: Evaluation of serum concentrations and electrocardiographic effects." Am Heart J 105 (1983): 12-5
"Product Information. Norpace (disopyramide)." Searle, Skokie, IL.

Cardioquin

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Cardioquin?

Disopyramide Sustained-Release Capsules

Generic Name: disopyramide

Brand name: Norpace, Norpace CR

Synonyms: Disopyramide

What is Disopyramide Sustained-Release Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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