Cardioquin and Neratinib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Neratinib may increase the blood levels and effects of quiNIDine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with neratinib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, liver, and/or kidney due to inhibition of P-glycoprotein-mediated drug efflux by neratinib. According to the product labeling, when a single 0.5 mg oral dose of the P-gp substrate digoxin was administered with multiple 240 mg oral doses of neratinib in a study of 18 healthy volunteers, mean digoxin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 54% and 32%, respectively, compared to administration of digoxin alone.

MANAGEMENT: Caution is advised when neratinib is used concurrently with drugs that are known P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever neratinib is added to or withdrawn from therapy.

Cardioquin

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Cardioquin?

Neratinib

Generic Name: neratinib

Brand name: Nerlynx

Synonyms: n.a.

What is Neratinib?