Cardioquin and Niraparib Tosylate

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

QuiNIDine may increase the blood levels and effects of niraparib. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with potent inhibitors of P-glycoprotein (P-gp) may increase the bioavailability of niraparib, which is a substrate of the efflux transporter. Increased levels of niraparib may lead to increased incidence of hematological toxicity (e.g., thrombocytopenia, anemia, neutropenia) and/or cardiovascular toxicity (e.g., hypertension, hypertensive crisis).

MANAGEMENT: Pharmacologic response to niraparib should be monitored more closely whenever a potent P-gp inhibitor is added to or withdrawn from therapy, and the niraparib dosage adjusted as necessary.

Cardioquin

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Cardioquin?

Niraparib Tosylate

Generic Name: niraparib

Brand name: Zejula

Synonyms: Niraparib

What is Niraparib Tosylate?