Cardioquin and Olysio

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Simeprevir may increase the blood levels of quiNIDine. This can increase the risk of serious side effects such as irregular heart rhythm and other cardiovascular problems. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with simeprevir may increase the plasma concentrations of certain antiarrhythmic agents that are metabolized by CYP450 1A2 or 3A4 such as amiodarone, disopyramide, flecainide, mexiletine, propafenone, and quinidine. In vivo, simeprevir mildly inhibits CYP450 1A2 and intestinal CYP450 3A4, but does not affect hepatic CYP450 3A4 activity. Serious and/or life-threatening reactions including cardiac arrhythmias like torsade de pointes may occur if antiarrhythmic drug levels are significantly increased.

MANAGEMENT: Caution is advised if simeprevir is prescribed in combination with antiarrhythmic agents that are metabolized by CYP450 1A2 or 3A4. Pharmacologic response and plasma antiarrhythmic drug levels should be monitored more closely whenever simeprevir is added to or withdrawn from therapy, and the antiarrhythmic dosage adjusted as necessary.

Cardioquin

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Cardioquin?

Olysio

Generic Name: simeprevir

Brand name: Olysio

Synonyms: n.a.

What is Olysio?