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Cardioquin and Ombitasvir, paritaprevir, ritonavir and dasabuvir

Determining the interaction of Cardioquin and Ombitasvir, paritaprevir, ritonavir and dasabuvir and the possibility of their joint administration.

Check result:

Cardioquin <> Ombitasvir, paritaprevir, ritonavir and dasabuvir

Relevance: 21.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using quiNIDine and ritonavir is not recommended. Using these drugs may cause serious problems with your heart. Call your doctor if you have pain or discomfort in your chest, feel short of breath, feel dizzy, lightheaded, or feel very weak. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

Professional:

CONTRAINDICATED: Coadministration with ritonavir may significantly increase the plasma concentrations of some antiarrhythmic agents such as amiodarone, bepridil, flecainide, propafenone, and quinidine. The proposed mechanism is ritonavir inhibition of CYP450 3A4 and/or 2D6, the isoenzymes responsible for the metabolic clearance of these agents. Although clinical data are lacking, the interaction could conceivably lead to serious and/or life-threatening reactions including QT interval prolongation and ventricular arrhythmias such as ventricular tachycardia and torsade de pointes.

MANAGEMENT: The use of ritonavir with amiodarone, bepridil, flecainide, propafenone, or quinidine is considered contraindicated.

References

Mangum EM, Graham KK "Lopinavir-Ritonavir: a new protease inhibitor." Pharmacotherapy 21 (2001): 1352-63
Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ([2006]):
"Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL.
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Cardioquin

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Cardioquin?

Ombitasvir, paritaprevir, ritonavir and dasabuvir

Generic Name: dasabuvir / ombitasvir / paritaprevir / ritonavir

Brand name: Viekira XR, Viekira Pak

Synonyms: Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Extended-Release Tablets, and Dasabuvir

What is Ombitasvir, paritaprevir, ritonavir and dasabuvir?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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