Cardioquin and Tylenol Maximum Strength Flu Nighttime
Determining the interaction of Cardioquin and Tylenol Maximum Strength Flu Nighttime and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: The use of higher than recommended dosages of diphenhydramine (e.g., through abuse or misuse) has been associated with serious and potentially fatal cardiac adverse events, including cardiac arrest, and arrhythmia related to prolongation of the QT interval. Coadministration with class Ia (e.g., disopyramide, quinidine, procainamide) and class III (e.g., amiodarone, dofetilide, sotalol) antiarrhythmic agents may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. In general, the risk of an individual agent or a combination of agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). In addition, the extent of drug-induced QT prolongation is dependent on the particular drug(s) involved and dosage(s) of the drug(s). MANAGEMENT: Australian authorities recommend avoiding concomitant use of diphenhydramine and class Ia or class III antiarrhythmic agents. Additionally, patients should be counseled to not exceed the recommended dosage and frequency or duration of use of diphenhydramine, and to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope. References Husain Z, Hussain K, Nair R, Steinman R "Diphenhydramine induced QT prolongation and torsade de pointes: An uncommon effect of a common drug." Cardiology 17 (2010): 509-11 Cerner Multum, Inc. "Australian Product Information." O 0 Shah A, Yousuf T, Ziffra J, Zaidi A, Raghuvir R "Diphenhydramine and QT prolongation - A rare cardiac side effect of a drug used in common practice." J Cardiol Cases 12 (2015): 126-9 Poluzzi E, Raschi E, Godman B, et.al "Pro-arrhythmic potential of oral antihistamines (H1): Combining adverse event reports with drug utilization data across Europe." PLoS One 10 (2014): epub View all 4 references
Professional:GENERALLY AVOID: The use of higher than recommended dosages of diphenhydramine (e.g., through abuse or misuse) has been associated with serious and potentially fatal cardiac adverse events, including cardiac arrest, and arrhythmia related to prolongation of the QT interval. Coadministration with class Ia (e.g., disopyramide, quinidine, procainamide) and class III (e.g., amiodarone, dofetilide, sotalol) antiarrhythmic agents may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. In general, the risk of an individual agent or a combination of agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). In addition, the extent of drug-induced QT prolongation is dependent on the particular drug(s) involved and dosage(s) of the drug(s).
MANAGEMENT: Australian authorities recommend avoiding concomitant use of diphenhydramine and class Ia or class III antiarrhythmic agents. Additionally, patients should be counseled to not exceed the recommended dosage and frequency or duration of use of diphenhydramine, and to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope.
- Husain Z, Hussain K, Nair R, Steinman R "Diphenhydramine induced QT prolongation and torsade de pointes: An uncommon effect of a common drug." Cardiology 17 (2010): 509-11
- Cerner Multum, Inc. "Australian Product Information." O 0
- Shah A, Yousuf T, Ziffra J, Zaidi A, Raghuvir R "Diphenhydramine and QT prolongation - A rare cardiac side effect of a drug used in common practice." J Cardiol Cases 12 (2015): 126-9
- Poluzzi E, Raschi E, Godman B, et.al "Pro-arrhythmic potential of oral antihistamines (H1): Combining adverse event reports with drug utilization data across Europe." PLoS One 10 (2014): epub
Generic Name: quinidine
Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release
Synonyms: n.a.
Generic Name: acetaminophen / diphenhydramine / pseudoephedrine
Brand name: Benadryl Allergy/Cold, Tylenol Maximum Strength Flu Nighttime
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cardioquin-Tylenol NightTime Cold & Flu
- Cardioquin-Tylenol PM
- Cardioquin-Tylenol Severe Allergy
- Cardioquin-Tylenol Sinus Congestion and Pain
- Cardioquin-Tylenol Sinus Congestion Nighttime
- Cardioquin-Tylenol Sinus Congestion/Pain (Acetaminophen and Phenylephrine Tablets)
- Tylenol Maximum Strength Flu Nighttime-Cardioxane Injection
- Tylenol Maximum Strength Flu Nighttime-Cardizem
- Tylenol Maximum Strength Flu Nighttime-Cardizem (Diltiazem Injection)
- Tylenol Maximum Strength Flu Nighttime-Cardizem (Diltiazem Tablets)
- Tylenol Maximum Strength Flu Nighttime-Cardizem CD
- Tylenol Maximum Strength Flu Nighttime-Cardizem Intravenous