Cardioquin and Vaprisol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using quiNIDine together with conivaptan. Combining these medications may significantly increase the blood levels and effects of quiNIDine. This can increase the risk of serious side effects such as irregular heart rhythm and other cardiovascular problems. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Coadministration with conivaptan may significantly increase the plasma concentrations of certain antiarrhythmic agents such as amiodarone, lidocaine, and quinidine. The mechanism is conivaptan inhibition of CYP450 3A4 metabolism. The interaction has not been specifically studied but could conceivably lead to serious and/or life-threatening reactions including cardiac arrhythmias and other toxicities. In pharmacokinetic studies with other drugs that are primarily metabolized by CYP450 3A4 such as midazolam, simvastatin, and amlodipine, conivaptan has increased systemic exposure (AUC) by 2- to 3-fold.

MANAGEMENT: Caution is advised if conivaptan must be used with antiarrhythmic agents that are primarily metabolized by CYP450 3A4 such as amiodarone, lidocaine, or quinidine. Pharmacologic response and plasma antiarrhythmic drug levels should be monitored more closely whenever conivaptan is added to or withdrawn from therapy, and the antiarrhythmic dosage adjusted as necessary.

Cardioquin

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Cardioquin?

Vaprisol

Generic Name: conivaptan

Brand name: Vaprisol

Synonyms: n.a.

What is Vaprisol?