Cardioxane Injection and Nerlynx

• Generic Name: dexrazoxane
• Dosage Forms: injection, powder, for solution
• Other Brand Names: Totect, Zinecard

Dexrazoxane is used to protect the heart and other tissues from harmful side effects caused by certain cancer medications.

The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an injected medicine escapes from the blood vessels and circulates into tissues in the body. Serious tissue damage can occur when extravasation happens during injection of certain cancer medications.

The Zinecard brand of dexrazoxane is used to help prevent chemotherapy-related heart problems in women who are receiving doxorubicin for metastatic breast cancer. Zinecard is given only after you have received enough doxorubicin infusions to amount to a certain total dose.

Dexrazoxane may also be used for purposes not listed in this medication guide.

• Generic Name: neratinib
• Dosage Forms: tablet
• Other Brand Names: Nerlynx

Nerlynx (neratinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Nerlynx is used to treat a certain type of early-stage breast cancer. It is used for this condition only if your tumor tests positive for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells.

Nerlynx is usually given after you have been treated with another medicine called trastuzumab (Herceptin).