Cardioxane Injection and Nizoral

• Generic Name: dexrazoxane
• Dosage Forms: injection, powder, for solution
• Other Brand Names: Totect, Zinecard

Dexrazoxane is used to protect the heart and other tissues from harmful side effects caused by certain cancer medications.

The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an injected medicine escapes from the blood vessels and circulates into tissues in the body. Serious tissue damage can occur when extravasation happens during injection of certain cancer medications.

The Zinecard brand of dexrazoxane is used to help prevent chemotherapy-related heart problems in women who are receiving doxorubicin for metastatic breast cancer. Zinecard is given only after you have received enough doxorubicin infusions to amount to a certain total dose.

Dexrazoxane may also be used for purposes not listed in this medication guide.

• Generic Name: ketoconazole
• Dosage Forms: tablet
• Other Brand Names: Nizoral

Nizoral (ketoconazole) is an antifungal medication that fights infections caused by fungus.

Nizoral is not for use in treating fungal infections of the fingernails or toenails. This medicine is also not for use in treating prostate cancer or Cushing syndrome.

Nizoral should be used only when you cannot use other antifungal medications. Ketoconazole can cause serious harm to your liver that may result in liver transplant or cause death.