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Cardizem and Digox Tablets

Determining the interaction of Cardizem and Digox Tablets and the possibility of their joint administration.

Check result:

Cardizem <> Digox Tablets

Relevance: 04.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking dilTIAZem, tell your doctor if you also use digoxin. You may need dose adjustments or special tests in order to safely take both medications together. This combination may increase digoxin levels. You should notify your doctor if you have symptoms of nausea, loss of appetite, visual changes, slow pulse, or irregular heartbeats. Your digoxin levels may need to be checked more frequently. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Diltiazem may cause increases in digoxin plasma levels although reports are conflicting. The mechanism for this possible interaction is unknown but is thought to be related to diltiazem-induced decreases in digoxin clearance. In addition, digoxin and diltiazem have additive effects in slowing AV conduction.

MANAGEMENT: Monitor for signs and symptoms of digoxin toxicity, checking digoxin levels when clinically necessary. Patients should be advised to notify their physicians if they experience signs of digoxin toxicity such as nausea, anorexia, visual changes, slow pulse, or irregular heartbeats. Calcium channel blockers such as felodipine, or amlodipine, isradipine, and nicardipine appear to affect digoxin levels to a lesser extent or not at all and may be considered as alternatives.

References

Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
Bloedow DC, Piepho RW, Nies AS, Gal J "Serum binding of diltiazem in humans." J Clin Pharmacol 22 (1982): 201-5
Kazierad DJ, Lalonde RL, Hoon TJ, Mirvis DM, Bottorff MB "The effect of diltiazem on the disposition of encainide and its active metabolites." Clin Pharmacol Ther 46 (1989): 668-73
Yosida A, Fujita M, Kurosawa N, et al "Effects of diltiazem on plasma level and urinary excretion of digoxin in healthy subjects." Clin Pharmacol Ther 35 (1984): 681-5
Beltrami TR, May JJ, Bertino JS Jr "Lack of effects of diltiazem on digoxin pharmacokinetics." J Clin Pharmacol 25 (1985): 390-2
Kulhmann J "Effects of verapamil, diltiazem, and nifedipine on plasma levels and renal excretion of digitoxin." Clin Pharmacol Ther 38 (1985): 667-73
Ramaeis H, Magometschnigg D, Ganzinger U "The diltiazem-digoxin interaction." Clin Pharmacol Ther 36 (1984): 183-9
Elkayam U, Parikh K, Torkan B, Weber L, Cohen JL, Rahimtoola SH "Effect of diltiazem on renal clearance and serum concentration of digoxin in patients with cardiac disease." Am J Cardiol 55 (1985): 1393-5
Andrejak M, Hary L, Andrejak MT, Lesbre JP "Diltiazem increases steady state digoxin serum levels in patients with cardiac disease." J Clin Pharmacol 27 (1987): 967-70
Jones WN, Kern KB, Rindone JP "Digoxin-diltiazem interaction: a pharmacokinetic evaluation." Eur J Clin Pharmacol 31 (1986): 351-3

Cardizem

Generic Name: diltiazem

Brand name: Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Dilt-XR, Tiazac, Cardizem LA, Tiazac Extended Release Capsules

Synonyms: n.a.

What is Cardizem?

Digox Tablets

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digox (Oral)

What is Digox Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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