Cardizem CD and Revatio

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

DilTIAZem may increase the blood levels and effects of sildenafil. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, and/or priapism (prolonged and painful erection unrelated to sexual activity), as these may be signs and symptoms of excessive sildenafil levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: The coadministration of diltiazem may increase the plasma concentrations of sildenafil. The mechanism is inhibition of CYP450 3A4 metabolism. While the extent of the interaction may vary, the possibility of prolonged and/or increased pharmacologic effects of sildenafil and of exaggerated or prolonged responses to nitrates should be considered. There may be a significant prolongation of the post-dose period during which use of nitrates is potentially hazardous. A 72-year-old male on a stable regimen which included diltiazem and metoprolol developed asymptomatic hypotension (central arterial pressure decreased from 160/90 to 90/60) after taking sublingual nitroglycerin during angiography. It was determined that he had taken an unprescribed 50 mg dose of sildenafil 48 hours before the procedure. Additive hypotensive effects by metoprolol and diltiazem may also have contributed to the nitrate-induced hypotension.

MANAGEMENT: Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy. The manufacturer recommends that an initial sildenafil dosage of 25 mg be considered in patients treated concomitantly with a potent CYP450 3A4 inhibitor. It is unknown when nitrates could be safely administered after a sildenafil dose and in the presence of a CYP450 3A4 inhibitor. Patients should be advised to promptly notify their physician if they experience pain or tightness in the chest or jaw, irregular heartbeat, nausea, shortness of breath, visual disturbances, syncope, or prolonged erection (greater than 4 hours).

Cardizem CD

Generic Name: diltiazem

Brand name: Cardizem CD, Cartia XT, Dilt-XR, Diltia XT, Taztia XT, Tiazac, Cardizem, Dilacor XR, Dilt-CD, Diltzac, Matzim LA, Tiazac, Cardizem LA, Tiazac Extended Release Capsules

Synonyms: n.a.

What is Cardizem CD?

Revatio

Generic Name: sildenafil

Brand name: Revatio, Viagra

Synonyms: n.a.

What is Revatio?