Drug search by name

Cardizem (Diltiazem Injection) and Procardia XL

Determining the interaction of Cardizem (Diltiazem Injection) and Procardia XL and the possibility of their joint administration.

Check result:

Cardizem (Diltiazem Injection) <> Procardia XL

Relevance: 26.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking dilTIAZem, tell your doctor if you also use NIFEdipine. You may need dose adjustments or special tests in order to safely take both medications together . The levels of dilTIAZem or NIFEdipine may be increased. You should notify your doctor if you have symptoms of low blood pressure such as headaches, faint, or slow heartbeats. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Diltiazem may increase the bioavailability and decrease the metabolism of nifedipine. Serum levels and effect of nifedipine may be increased. In addition, nifedipine may increase plasma diltiazem concentrations. The pharmacologic effects of both medications may be additive. Increased risk of hypotension and conduction disturbances may result. The mechanism may be reduced hepatic clearance.

MANAGEMENT: If these agents must be used concomitantly, close monitoring for altered efficacy and safety is recommended. Dose adjustments may be required. Patients should be advised to notify their physician if they experience headaches, syncope, or slow heartbeats.

References

Ohashi K, Tateishi T, Sudo T, et al "Effects of diltiazem on the pharmacokinetics of nifedipine." J Cardiovasc Pharmacol 15 (1990): 96-101
Tateishi T, Ohashi K, Sudo T, et al "Dose dependent effect of diltiazem on the pharmacokinetics of nifedipine." J Clin Pharmacol 29 (1989): 994-7
Toyosaki N, Toyo-oka T, Natsume T, et al. "Combination therapy with diltiazem and nifedipine in patients with effort angina pectoris." Circulation 77 (1988): 1370-5

Cardizem (Diltiazem Injection)

Generic Name: diltiazem

Brand name: Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Dilt-XR, Tiazac, Cardizem LA, Tiazac Extended Release Capsules

Synonyms: Cardizem

What is Cardizem (Diltiazem Injection)?

Procardia XL

Generic Name: nifedipine

Brand name: Adalat CC, Procardia, Procardia XL, Afeditab CR, Nifediac CC, Nifedical XL, Adalat

Synonyms: n.a.

What is Procardia XL?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions