Cardizem (Diltiazem Tablets) and Clonidine
Determining the interaction of Cardizem (Diltiazem Tablets) and Clonidine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using cloNIDine together with dilTIAZem may cause excessively low blood pressure and heart rate. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of clonidine with agents known to affect sinus node function of AV nodal conduction may be associated with significantly reduced heart rate. Sinus bradycardia and complete AV block resulting in hospitalization and pacemaker insertion have been reported during the concomitant use of clonidine and diltiazem or verapamil. The exact mechanism of interaction is unknown. However, these drugs individually have been associated with AV node dysfunction and may have additive effects during coadministration.
MANAGEMENT: Heart rate and blood pressure should be closely monitored in patients receiving clonidine in combination with agents known to affect sinus node function of AV nodal conduction such as digitalis and certain calcium channel blockers.
- "Product Information. Cardizem (diltiazem)." Hoechst Marion-Roussel Inc, Kansas City, MO.
- "Product Information. Verelan PM (verapamil)." Schwarz Pharma, Mequon, WI.
- "Product Information. Catapres (clonidine)." Boehringer-Ingelheim, Ridgefield, CT.
- Jaffe R, Livshits T, Bursztyn M "Adverse interaction between clonidine and verapamil." Ann Pharmacother 28 (1994): 881-3
Generic Name: diltiazem
Brand name: Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Dilt-XR, Tiazac, Cardizem LA, Tiazac Extended Release Capsules
Synonyms: Cardizem
Generic Name: clonidine
Brand name: Catapres, Kapvay, Catapres-TTS, Duraclon, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3
Synonyms: CloNIDine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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