Cardizem LA and Flecainide Acetate
Determining the interaction of Cardizem LA and Flecainide Acetate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using dilTIAZem together with flecainide can increase the effects of either medication. This can cause dizziness, weakness, chest pain, shortness of breath, fainting, an unusually fast or slow heartbeat, coma, slurred speech, and confusion. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR CLOSELY: Limited data indicate that verapamil and flecainide may have additive cardiodepressant effects. In pharmacokinetic studies with healthy volunteers, there were minor effects on drug plasma concentrations and QRS intervals were prolonged. However, cases of cardiogenic shock, asystole, and death have been reported in patients receiving flecainide and verapamil. Diltiazem may interact with flecainide in a similar manner, although no data are available.
MANAGEMENT: The patient should be monitored closely when either drug is added to the regimen or when dose increases are made.
- Holtzman JL, Finley D, Mottonen L, et al "The pharmacodynamic and pharmacokinetic interaction between single doses of flecainide acetate and verapamil: effects on cardiac function and drug clearance." Clin Pharmacol Ther 46 (1989): 26-32
- Buss J, Lasserre JJ, Heene DL "Asystole and cardiogenic shock due to combined treatment with verapamil and flecainide." Lancet 340 (1992): 546
- Holtzman JL, Finley D, Mottonen L, et al "Pharmacodynamic and pharmacokinetic interaction of flecanide and verapamil." Clin Pharmacol Ther Feb (1987): 242
- Minish T, Herd A "Symptomatic bradycardia secondary to interaction between topical timolol maleate, verapamil, and flecainide: a case report." J Emerg Med 22 (2002): 247-9
Generic Name: diltiazem
Brand name: Cardizem LA, Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Dilt-XR, Tiazac, Tiazac Extended Release Capsules
Synonyms: n.a.
Generic Name: flecainide
Brand name: Tambocor
Synonyms: Flecainide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cardizem LA-Flector
- Cardizem LA-Flector Topical
- Cardizem LA-Fleet (Glycerin Enema)
- Cardizem LA-Fleet (Mineral Oil Enema)
- Cardizem LA-Fleet (Sodium Phosphates Enema)
- Cardizem LA-Fleet Babylax
- Flecainide Acetate-Cardura
- Flecainide Acetate-Cardura XL
- Flecainide Acetate-Care One Acid Reducer Plus Antacid
- Flecainide Acetate-Care One Sleep Aid
- Flecainide Acetate-Careone Acid Reducer
- Flecainide Acetate-Careone Hair Regrowth Treatment for Men