Cardizem LA and Sodium Nitroprusside
Determining the interaction of Cardizem LA and Sodium Nitroprusside and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The dosage of nitroprusside required to achieve a given hypotensive response is reduced by an average of 50% when diltiazem is coadministered. The mechanism is unknown. Since the risk of side effects from nitroprusside may be significantly decreased with a lower dose, this interaction may be advantageous.
- Bernard JM, Moren J, Demeure D, Mommeril JL, Pinaud M "Diltiazem reduces the nitroprusside doses for deliberate hypotension." Anesthesiology 77 (1992): a427
Generic Name: diltiazem
Brand name: Cardizem LA, Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Dilt-XR, Tiazac, Tiazac Extended Release Capsules
Synonyms: n.a.
Generic Name: nitroprusside
Brand name: Nitropress, Nipride RTU
Synonyms: Nitroprusside
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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