Cardizem LA and Vanspar
Determining the interaction of Cardizem LA and Vanspar and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before using dilTIAZem, tell your doctor if you also use busPIRone. This can cause drowsiness, feeling light-headed, uneven heart rate, depressed mood, unusual thoughts or behavior, or lack coordination. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The concomitant administration of diltiazem may increase buspirone levels and the risk of adverse effects. In one study (n=9), buspirone AUC increased by 5.5-fold and maximum plasma concentrations increased 4.1-fold after 5 doses of diltiazem. The proposed mechanism is inhibition of CYP450 3A4 first pass metabolism by diltiazem.
MANAGEMENT: The patient should be monitored carefully for signs of buspirone toxicity (e.g., drowsiness, dizziness, nervousness, insomnia, headache, nausea, vomiting). Alternatively, use of a dihydropyridine calcium channel blocker or an anxiolytic which is not a substrate of CYP450 3A4 may be appropriate.
- Lamberg TS, Kivisto KT, Neuvonen PJ "Effects of verapamil and diltiazem on the pharmacokinetics and pharmacodynamics of buspirone." Clin Pharmacol Ther 63 (1998): 640-5
Generic Name: diltiazem
Brand name: Cardizem LA, Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Dilt-XR, Tiazac, Tiazac Extended Release Capsules
Synonyms: n.a.
Generic Name: buspirone
Brand name: Buspar, Buspar Dividose, Vanspar, Buspirex, Bustab, LinBuspirone
Synonyms: Vanspar (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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