Cariprazine Hydrochloride and Isavuconazonium Sulfate Injection
Determining the interaction of Cariprazine Hydrochloride and Isavuconazonium Sulfate Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Isavuconazonium may increase the blood levels of cariprazine. In some cases, this may increase the risk of side effects such as drowsiness, Parkinson-like symptoms, abnormal muscle movements, seizures, high blood sugar, diabetes, high cholesterol, weight gain, low white blood cell count, difficulty swallowing, and heat-related disorders such as heat intolerance or heat stroke. You may also be more likely to experience side effects associated with low blood pressure such as dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with moderate inhibitors of CYP450 3A4 may increase the plasma concentrations of cariprazine and its major active metabolite, didesmethyl cariprazine (DDCAR), both of which are primarily metabolized by the isoenzyme. When cariprazine (0.5 mg/day) was coadministered with the potent CYP450 3A4 inhibitor, ketoconazole (400 mg/day), cariprazine peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 3.5- and 4-fold, respectively, while Cmax and AUC of DDCAR increased by approximately 1.5-fold each. The Cmax and AUC of another active metabolite, desmethyl cariprazine (DCAR), decreased by approximately one-third. The extent to which other, less potent inhibitors of CYP450 3A4 may interact with cariprazine and its metabolites is unknown.
MANAGEMENT: Caution is advised when cariprazine is prescribed with moderate CYP450 3A4 inhibitors. Patients should be monitored for adverse effects such as extrapyramidal symptoms, cognitive and motor impairment, hyperglycemia, dyslipidemia, weight gain, orthostatic hypotension, leukopenia, neutropenia, seizures and dysphagia, and the dosage of cariprazine adjusted as necessary in accordance with the product labeling.
- "Product Information. Vraylar (cariprazine)." Actavis Pharma, Inc., Parsippany, NJ.
Generic Name: cariprazine
Brand name: Vraylar
Synonyms: Cariprazine
Generic Name: isavuconazonium
Brand name: Cresemba
Synonyms: Isavuconazonium, Isavuconazonium Sulfate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cariprazine Hydrochloride-Isentress
- Cariprazine Hydrochloride-Isentress (Raltegravir Chewable Tablets)
- Cariprazine Hydrochloride-Isentress (Raltegravir Powder for Oral Suspension)
- Cariprazine Hydrochloride-Isentress (Raltegravir Tablets)
- Cariprazine Hydrochloride-Isentress HD
- Cariprazine Hydrochloride-Isibloom
- Isavuconazonium Sulfate Injection-Carisoprodol
- Isavuconazonium Sulfate Injection-Carisoprodol and Aspirin
- Isavuconazonium Sulfate Injection-Carisoprodol, Aspirin, and Codeine
- Isavuconazonium Sulfate Injection-Carlson D
- Isavuconazonium Sulfate Injection-Carmol HC
- Isavuconazonium Sulfate Injection-Carmustine