Carisoprodol and Aspirin and Divalproex sodium
Determining the interaction of Carisoprodol and Aspirin and Divalproex sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking aspirin, tell your doctor if you also use divalproex sodium. You may need dose adjustments or special tests in order to safely take both medications together. Small single doses of aspirin are unlikely to cause significant effects. However, if you take aspirin over a prolonged period of time you may need your divalproex sodium levels checked. You should notify your doctor if you have symptoms of fever, weakness, drowsiness, nausea, vomiting, or stomach pain. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Salicylates, particularly aspirin, may displace valproate from protein binding sites and inhibit its clearance. Four-fold increases in the free fraction of valproate have been reported in children. Increased therapeutic and toxic effects may be expected to occur. This interaction is more likely with large or prolonged doses of salicylates.
MANAGEMENT: Small single doses of salicylates are unlikely to cause significant effects. However, patients who take large doses of salicylates or over a prolonged period of time should be closely monitored for clinical and laboratory evidence of valproate toxicity and hepatotoxicity. Free fraction of valproate may be particularly helpful in detecting this interaction. Patients should be advised to notify their physician if they experience possible symptoms of toxicity (e.g., malaise, weakness, lethargy, drowsiness, nausea, vomiting, or abdominal pain).
- Farrell K, Orr JM, Abbott FS, et al "The effect of acetylsalicylic acid on serum free valproate concentrations and valproate clearance in children." J Pediatr 101 (1982): 142-4
- Dasgupta A, Jacques M "Reduced in vitro displacement of valproic acid from protein binding by salicylate in uremic sera compared with normal sera - role of uremic compounds." Am J Clin Pathol 101 (1994): 349-53
- Abbott FS, Kassam J, Orr JM, Farrell K "The effect of aspirin on valproic acid metabolism." Clin Pharmacol Ther 40 (1986): 94-100
- Orr JM, Abbott FS, Farrell K, Ferguson S, Sheppard I, Godolphin W "Interaction between valproic acid and aspirin in epileptic children: serum protein binding and metabolic effects." Clin Pharmacol Ther 31 (1982): 642-9
Generic Name: aspirin / carisoprodol
Brand name: Soma Compound, Carisoprodol Compound
Synonyms: Aspirin and carisoprodol
Generic Name: divalproex sodium
Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon
Synonyms: Divalproex
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Carisoprodol and Aspirin-Divalproex Sprinkle
- Carisoprodol and Aspirin-Divalproex Sprinkle Capsules
- Carisoprodol and Aspirin-Divigel
- Carisoprodol and Aspirin-Divigel 0.75 mg/packet for use on skin
- Carisoprodol and Aspirin-Divigel Transdermal
- Carisoprodol and Aspirin-Divista
- Divalproex sodium-Carisoprodol, Aspirin, and Codeine
- Divalproex sodium-Carlson D
- Divalproex sodium-Carmol HC
- Divalproex sodium-Carmustine
- Divalproex sodium-Carmustine Implantation
- Divalproex sodium-Carmustine Injection