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Carnexiv and Flagyl

Determining the interaction of Carnexiv and Flagyl and the possibility of their joint administration.

Check result:
Carnexiv <> Flagyl
Relevance: 27.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before using carBAMazepine, tell your doctor if you also use metroNIDAZOLE. This combination may cause restlessness, seizures, tremors, slurred speech, staggering walk, and feeling light-headed or fainting. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment if you take both medications. Avoid driving until you know how the medications will affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Metronidazole may significantly increase serum carbamazepine concentrations. One case of carbamazepine toxicity has been reported. The mechanism is unknown and causality was not clearly determined.

MANAGEMENT: Until more information is available, serum carbamazepine concentrations and clinical effects should be closely monitored during coadministration of metronidazole and after discontinuation. Patients should be advised to report possible symptoms of carbamazepine toxicity (nausea, visual disturbances, dizziness, or ataxia).

References
  • Patterson BD "Possible interaction between metronidazole and carbamazepine." Ann Pharmacother 28 (1994): 1303-4
Carnexiv

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carnexiv (Intravenous)

Flagyl

Generic Name: metronidazole

Brand name: Flagyl, FIRST Metronidazole, Flagyl 375, MetroGel

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction