Drug search by name

Carnexiv and PCE Dispertab

Determining the interaction of Carnexiv and PCE Dispertab and the possibility of their joint administration.

Check result:

Carnexiv <> PCE Dispertab

Relevance: 27.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using carBAMazepine and erythromycin. Alternative antibiotic therapy, if available, is generally recommended if you are on carBAMazepine. This combination may cause nausea, visual disturbances, dizziness, or poor muscle coordination. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special test if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Some macrolide antibiotics can significantly increase serum carbamazepine levels. The mechanism is probably inhibition of hepatic CYP450 3A4 isoenzymes. Severe carbamazepine toxicity has been reported.

MANAGEMENT: Alternative antimicrobial therapy, if available, is generally recommended for patients on carbamazepine. A macrolide that does not affect carbamazepine levels, such as azithromycin, may be substituted if clinically appropriate. If this combination must be used, carbamazepine levels should be monitored and the patient should be carefully observed for signs of carbamazepine toxicity. Patients should be advised to report signs of carbamazepine toxicity (nausea, visual disturbances, dizziness, or ataxia) to their physicians. The carbamazepine dosage may require reduction.

References

Dammann HG "Therapy with omeprazole and clarithromycin increases serum carbamazepine levels in patients with h-pylori gastritis." Dig Dis Sci 41 (1996): 519
Hedrick R, Williams F, Morin R, Lamb WA, Cate JC "Carbamazepine-erythromycin interaction leading to carbamazepine toxicity in four epileptic children." Ther Drug Monit 5 (1983): 405-7
Metz DC, Getz HD "Helicobacter pylori gastritis therapy with omeprazole and clarithromycin increases serum carbamazepine levels." Dig Dis Sci 40 (1995): 912-5
Jaster PJ, Abbas D "Erythromycin-carbamazepine interaction." Neurology 36 (1986): 594-5
Keranen T, Jolkkonen J, Jensen PK, Menge GP, Andersson P "Absence of interaction between oxcarbazepine and erythromycin." Acta Neurol Scand 86 (1992): 120-3
Amsden GW "Macrolides versus azalides: a drug interaction update." Ann Pharmacother 29 (1995): 906-17
Goulden KJ, Camfield P, Dooley JM, et al "Severe carbamazepine intoxication after coadministration with erythromycin." J Pediatr 109 (1986): 135-8
Mesdjian E, Dravet C, Cenraud B, Roger J "Carbamazepine intoxication due to triacetyloleandomycin administration in epileptic patients." Epilepsia 21 (1980): 489-96
Dravet C, Mesdjian E, Cenraud B, Roger J "Interaction between carbamazepine and triacetyloleandomycin." Lancet 1 (1977): 810-1
Wong YY, Ludden TM, Bell RD "Effect of erythromycin on carbamazepine kinetics." Clin Pharmacol Ther 33 (1983): 460-4
Stafstrom CE, Nohria V, Loganbill H, Nahouraii R, Boustany RM, Delong GR "Erythromycin-induced carbamazepine toxicity: a continuing problem." Arch Pediatr Adolesc Med 149 (1995): 99-101
Albani F, Riva R, Baruzzi A "Clarithromycin-carbamazepine interaction: a case report." Epilepsia 34 (1993): 161-2
Berrettini WH "A case of erythromycin-induced carbamazepine toxicity." J Clin Psychiatry 47 (1986): 147
Vajda FJ, Bladin PF "Carbamazepine-erythromycin-base interaction." Med J Aust Jan (1984): 81

Carnexiv

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carnexiv (Intravenous)

What is Carnexiv?

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions