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CaroSpir and Cholestyramine Light

Determining the interaction of CaroSpir and Cholestyramine Light and the possibility of their joint administration.

Check result:

CaroSpir <> Cholestyramine Light

Relevance: 17.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using spironolactone together with cholestyramine may alter the effects of spironolactone. Contact your doctor if you experience numbness or tingly feeling, muscle pain or weakness, slow, fast, or uneven heartbeat, feeling drowsy, restless, or light-headed, urinating less than usual, shallow breathing, tremors, confusion, or nausea. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Rare cases of severe hyperchloremic, hyperkalemic, metabolic acidosis have been associated with coadministration of spironolactone and cholestyramine. While spironolactone alone can cause metabolic acidosis, the addition of cholestyramine could provide an anion exchange of chloride for bicarbonate in the small bowel. The resulting loss of bicarbonate predisposes the patient to a hyperchloremic, nonanion gap, metabolic acidosis in the presence of renal failure.

MANAGEMENT: If these drugs must be used together, careful monitoring of electrolytes and metabolic status is strongly recommended, particularly in the presence of renal insufficiency.

References

Zapater P, Alba D "Acidosis and extreme hyperkalemia associated with cholestyramine and spironolactone." Ann Pharmacother 29 (1995): 199-200

CaroSpir

Generic Name: spironolactone

Brand name: Aldactone, CaroSpir

Synonyms: n.a.

What is CaroSpir?

Cholestyramine Light

Generic Name: cholestyramine

Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets

Synonyms: n.a.

What is Cholestyramine Light?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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