CaroSpir and Hydrochlorothiazide and amiloride

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using aMILoride together with spironolactone is generally not recommended. Combining these medications may cause hyperkalemia (high blood potassium), which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia while taking these medications if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. Regular or long-term use of nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen (Aleve) may also increase your risk. It is important that you maintain adequate fluid intake during treatment with aMILoride or spironolactone. In addition, talk to your doctor to see if you should limit consumption of potassium-rich foods such as tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes, and potassium-containing salt substitutes. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: The principal risk of potassium-sparing diuretics is hyperkalemia. There may be an additive risk when more than one of these agents are used simultaneously. Death has been reported in patients receiving spironolactone in combination with triamterene-containing diuretics.

MANAGEMENT: Given the potential for serious, sometimes fatal cardiac arrhythmias associated with hyperkalemia, the concurrent use of more than one potassium-sparing diuretic is considered contraindicated.

CaroSpir

Generic Name: spironolactone

Brand name: Aldactone, CaroSpir

Synonyms: n.a.

What is CaroSpir?

Hydrochlorothiazide and amiloride

Generic Name: amiloride / hydrochlorothiazide

Brand name: Moduretic 5-50

Synonyms: Amiloride and Hydrochlorothiazide

What is Hydrochlorothiazide and amiloride?