CaroSpir and Methenamine, Phenyl Salicylate, Methylene Blue, Benzoic Acid, Hyoscyamine
Determining the interaction of CaroSpir and Methenamine, Phenyl Salicylate, Methylene Blue, Benzoic Acid, Hyoscyamine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Some salicylates may impair the tubular secretion of canrenone, the main active metabolite of spironolactone. This effect could inhibit the natriuretic properties of spironolactone. Data are available for aspirin. If diuresis is inadequate, the clinician should consider discontinuing the salicylate or increasing spironolactone dosage while paying careful attention to the patient's serum potassium concentration.
- Kramer HJ, Dusing R, Stinnesbeck B, et al. "Interaction of conventional and antikaliuretic diuretics with the renal prostaglandin system." Clin Sci 59 (1980): 67-70
- Favre L, Glasson P, Riondel A, Vallotton MB "Interaction of diuretics and non-steroidal anti-inflammatory drugs in man." Clin Sci 64 (1983): 407-15
- Tweeddale MG, Ogilvie RI "Antagonism of spironolactone-induced natriuresis by aspirin in man." N Engl J Med 289 (1973): 198-200
Generic Name: spironolactone
Brand name: Aldactone, CaroSpir
Synonyms: n.a.
Generic Name: benzoic acid / hyoscyamine / methenamine / methylene blue / phenyl salicylate
Brand name: Hyophen, Prosed/DS, Urophen MB
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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