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Carospir Suspension and Lanoxicaps

Determining the interaction of Carospir Suspension and Lanoxicaps and the possibility of their joint administration.

Check result:

Carospir Suspension <> Lanoxicaps

Relevance: 21.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Spironolactone may reduce the tubular secretion of digoxin. Plasma clearance of digoxin may be decreased, and plasma levels may increase. Also, limited data indicate that spironolactone may have a negative inotropic side effect. Finally, spironolactone may interfere with some digoxin radioimmunoassays, and digoxin concentrations may be overestimated. During coadministration, the patient should be monitored for signs and symptoms of digoxin toxicity, levels should be checked when necessary, and the clinician should keep in mind the possibility that digoxin levels may falsely appear to be elevated. Patients should be advised to notify their physician if they experience nausea, anorexia, visual changes, or irregular heartbeats.

References

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Drescher S, Glaeser H, Murdter T, Hitzl M, Eichelbaum M, Fromm MF "P-glycoprotein-mediated intestinal and biliary digoxin transport in humans." Clin Pharmacol Ther 73 (2003): 223-31
Wirth KE, Frolich JC, Hollifield JW, et al "Metabolism of digitoxin in man and its modification by spironolactone." Eur J Clin Pharmacol 9 (1976): 345-54
Hsieh YY, Lin MS, Chen JH, et al "Spironolactone-digoxin interaction." Taiwan I Hsueh Hui Tsa Chih 82 (1983): 47-60
Whang R, Oei TO, Watanabe A "Frequency of hypomagnesemia in hospitalized patients receiving digitalis." Arch Intern Med 145 (1985): 655-6
Thomas RW, Maddox RR "The interaction of spironolactone and digoxin: a review and evaluation." Ther Drug Monit 3 (1981): 117-20
Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
Fenster PE, Hager WD, Goodman MM "Digoxin-quinidine-spironolactone interaction." Clin Pharmacol Ther 36 (1984): 70-3
Cohen L, Kitzes R "Magnesium Sulfate and digitalis-toxic arrhythmias." JAMA 249 (1983): 2808-10
Hedman A, Angelin B, Arvidsson A, Dahlqvist R "Digoxin-interactions in man: spironolactone reduces renal but not biliary digoxin clearance." Eur J Clin Pharmacol 42 (1992): 481-5
Finnegan TP, Spence JD, Cape RD "Potassium-sparing diuretics: interaction with digoxin in elderly men." J Am Geriatr Soc 32 (1984): 129-31
Morris RG, Lagnado PY, Lehmann DR, et al "Spironolactone as a source of interference in commercial digoxin immunoassays." Ther Drug Monit 9 (1987): 208-11
de Cos MA, Gomez-Ullate J, Gomez F, Armijo JA "Time course of trough serum gentamicin concentrations in preterm and term neonates." Clin Pharmacokinet 23 (1992): 391-401
Carruthers SG, Dujovne CA "Cholestyramine and spironolactone and their combination in digitoxin elimination." Clin Pharmacol Ther 27 (1980): 184-7
Balayssac D, Authier N, Cayre A, Coudore F "Does inhibition of P-glycoprotein lead to drug-drug interactions?" Toxicol Lett 156 (2005): 319-29
Waldorff S, Hansen PB, Egeblad H, et al "Interactions between digoxin and potassium-sparing diuretics." Clin Pharmacol Ther 33 (1983): 418-23
Waldorff S, Andersen JD, Heeboll-Nielsen N, et al. "Spironolactone-induced changes in digoxin kinetics." Clin Pharmacol Ther 24 (1978): 162-7
DiPiro JT, Cote JR, DiPiro CR, Bustrack JA "Spironolactone interference with digoxin radioimmunoassay in cirrhotic patients." Am J Hosp Pharm 37 (1980): 1518-21
Paladino JA, Davidson KH, McCall BB "Influence of spironolactone on serum digoxin concentration ." JAMA 251 (1984): 470-1

Carospir Suspension

Generic Name: spironolactone

Brand name: Aldactone, CaroSpir

Synonyms: Spironolactone

What is Carospir Suspension?

Lanoxicaps

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Lanoxicaps (Oral)

What is Lanoxicaps?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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