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Cartia XT and Lasmiditan

Determining the interaction of Cartia XT and Lasmiditan and the possibility of their joint administration.

Check result:
Cartia XT <> Lasmiditan
Relevance: 11.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.MONITOR: Coadministration of lasmiditan and agents that lower heart rate may increase the risk of bradycardia. In clinical trials, lasmiditan was associated with heart rate decreases of 5 to 10 beats per minute (bpm) while placebo was associated with decreases of 2 to 5 bpm. In a drug interaction study, a single 200 mg dose of lasmiditan led to an additional heart rate decrease of 5 bpm when given with propranolol. MANAGEMENT: Caution is advised during coadministration of lasmiditan and agents that lower heart rate if the estimated decrease in heart rate may present a clinical risk. Consider monitoring heart rate in patients for whom the estimated decrease in heart rate may not be tolerated. References "Product Information. Reyvow (lasmiditan)." Lilly, Eli and Company, Indianapolis, IN.

Professional:

MONITOR: Coadministration of lasmiditan and agents that lower heart rate may increase the risk of bradycardia. In clinical trials, lasmiditan was associated with heart rate decreases of 5 to 10 beats per minute (bpm) while placebo was associated with decreases of 2 to 5 bpm. In a drug interaction study, a single 200 mg dose of lasmiditan led to an additional heart rate decrease of 5 bpm when given with propranolol.

MANAGEMENT: Caution is advised during coadministration of lasmiditan and agents that lower heart rate if the estimated decrease in heart rate may present a clinical risk. Consider monitoring heart rate in patients for whom the estimated decrease in heart rate may not be tolerated.

References
  • "Product Information. Reyvow (lasmiditan)." Lilly, Eli and Company, Indianapolis, IN.
Cartia XT

Generic Name: diltiazem

Brand name: Cardizem CD, Cartia XT, Dilt-XR, Diltia XT, Taztia XT, Tiazac, Cardizem, Dilacor XR, Dilt-CD, Diltzac, Matzim LA, Tiazac, Cardizem LA, Tiazac Extended Release Capsules

Synonyms: n.a.

Lasmiditan

Generic Name: lasmiditan

Brand name:

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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