Cartia XT and Nifedipine Extended-Release Tablets
Determining the interaction of Cartia XT and Nifedipine Extended-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking dilTIAZem, tell your doctor if you also use NIFEdipine. You may need dose adjustments or special tests in order to safely take both medications together . The levels of dilTIAZem or NIFEdipine may be increased. You should notify your doctor if you have symptoms of low blood pressure such as headaches, faint, or slow heartbeats. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Diltiazem may increase the bioavailability and decrease the metabolism of nifedipine. Serum levels and effect of nifedipine may be increased. In addition, nifedipine may increase plasma diltiazem concentrations. The pharmacologic effects of both medications may be additive. Increased risk of hypotension and conduction disturbances may result. The mechanism may be reduced hepatic clearance.
MANAGEMENT: If these agents must be used concomitantly, close monitoring for altered efficacy and safety is recommended. Dose adjustments may be required. Patients should be advised to notify their physician if they experience headaches, syncope, or slow heartbeats.
- Ohashi K, Tateishi T, Sudo T, et al "Effects of diltiazem on the pharmacokinetics of nifedipine." J Cardiovasc Pharmacol 15 (1990): 96-101
- Tateishi T, Ohashi K, Sudo T, et al "Dose dependent effect of diltiazem on the pharmacokinetics of nifedipine." J Clin Pharmacol 29 (1989): 994-7
- Toyosaki N, Toyo-oka T, Natsume T, et al. "Combination therapy with diltiazem and nifedipine in patients with effort angina pectoris." Circulation 77 (1988): 1370-5
Generic Name: diltiazem
Brand name: Cardizem CD, Cartia XT, Dilt-XR, Diltia XT, Taztia XT, Tiazac, Cardizem, Dilacor XR, Dilt-CD, Diltzac, Matzim LA, Tiazac, Cardizem LA, Tiazac Extended Release Capsules
Synonyms: n.a.
Generic Name: nifedipine
Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat
Synonyms: Nifedipine, NIFEdipine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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