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Carvedilol Extended-Release Capsules and Dobutamine in Dextrose

Determining the interaction of Carvedilol Extended-Release Capsules and Dobutamine in Dextrose and the possibility of their joint administration.

Check result:
Carvedilol Extended-Release Capsules <> Dobutamine in Dextrose
Relevance: 07.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using DOBUTamine together with carvedilol may alter the effects of both medications and cause your blood pressure to become too low. This can cause a slow heartbeat, headaches, dizziness, or feeling like you might pass out. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: A case of marked hypotension resulting from concomitant use of low dose carvedilol with dobutamine has been reported. The mechanism may be related to a decrease in systemic vascular resistance from dobutamine and blockade of the increase in cardiac output due to the beta blocker activity of carvedilol. In animal studies, however, the effectiveness of dobutamine was decreased and peripheral vascular resistance increased in the presence of beta-blockers.

MANAGEMENT: Close monitoring of the patient's blood pressure is recommended during concurrent administration.

References
  • Lindenfeld JA, Lowes BD, Bristow MR "Hypotension with dobutamine: B-adrenergic antagonist selectivity at low doses of carvedilol." Ann Pharmacother 33 (1999): 1266-9
  • "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company, Indianapolis, IN.
Carvedilol Extended-Release Capsules

Generic Name: carvedilol

Brand name: Coreg, Coreg CR

Synonyms: Carvedilol

Dobutamine in Dextrose

Generic Name: dobutamine

Brand name: Dobutrex

Synonyms: Dobutamine, DOBUTamine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.