Carvedilol Extended-Release Capsules and Ivabradine Hydrochloride
Determining the interaction of Carvedilol Extended-Release Capsules and Ivabradine Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Both ivabradine and carvedilol can slow the heart rate, and using them together may increase this effect and cause conduction problems and irregular heart rhythm. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if you develop significant decreases in heart rate or symptoms such as dizziness, lightheadedness, fainting, or low blood pressure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of ivabradine with other drugs that can slow the heart rate such as beta-blockers, calcium channel blockers, and digitalis may increase the risk of excessive bradycardia or other conduction disturbances. Non-cardiac drugs that may also cause bradycardia include atazanavir, fingolimod, lacosamide, lithium, mefloquine, succinylcholine, thalidomide, H2-receptor antagonists, tricyclic antidepressants, and anticholinesterase or cholinergic agents.
MANAGEMENT: Caution is advised when ivabradine is prescribed with other bradycardic drugs. Heart rate should be closely monitored, and the dosage of ivabradine adjusted accordingly. Patients should be advised to report significant decreases in heart rate or symptoms such as dizziness, lightheadedness, fatigue, and hypotension.
- "Product Information. Corlanor (ivabradine)." Amgen USA, Thousand Oaks, CA.
Generic Name: carvedilol
Brand name: Coreg, Coreg CR
Synonyms: Carvedilol
Generic Name: ivabradine
Brand name: Corlanor
Synonyms: Ivabradine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Carvedilol Extended-Release Capsules-Ivabradine Oral Solution
- Carvedilol Extended-Release Capsules-Ivabradine Tablets
- Carvedilol Extended-Release Capsules-Ivacaftor
- Carvedilol Extended-Release Capsules-Ivacaftor and lumacaftor
- Carvedilol Extended-Release Capsules-Ivacaftor and tezacaftor
- Carvedilol Extended-Release Capsules-Ivacaftor Granules
- Ivabradine Hydrochloride-Carvedilol Tablets
- Ivabradine Hydrochloride-Cascara
- Ivabradine Hydrochloride-Casodex
- Ivabradine Hydrochloride-Caspofungin
- Ivabradine Hydrochloride-Caspofungin Acetate
- Ivabradine Hydrochloride-Caspofungin Acetate Injection