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Casodex and Cisapride Suspension

Determining the interaction of Casodex and Cisapride Suspension and the possibility of their joint administration.

Check result:

Casodex <> Cisapride Suspension

Relevance: 28.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Cisapride in no longer on the market in the US. Do not take cisapride with any other medication.

Professional:

GENERALLY AVOID: Bicalutamide inhibits the CYP450 3A4 enzyme in vitro and may theoretically interfere with the metabolism of cisapride and terfenadine. The accumulation of cisapride or terfenadine may prolong the QT interval and possibly may lead to the development of ventricular arrhythmias, including torsades de pointes. Clinical data have not been reported.

MANAGEMENT: Concomitant administration should generally by avoided.

References

Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
"Product Information. Casodex (bicalutamide)." Zeneca Pharmaceuticals, Wilmington, DE.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0

Casodex

Generic Name: bicalutamide

Brand name: Casodex

Synonyms: n.a.

What is Casodex?

Cisapride Suspension

Generic Name: cisapride

Brand name: Propulsid

Synonyms: Cisapride Tablets

What is Cisapride Suspension?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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