Caspofungin Acetate Injection and Envarsus XR

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using caspofungin together with tacrolimus may decrease the effects of tacrolimus. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Caspofungin may reduce the plasma concentrations of tacrolimus. In healthy subjects, the area under the concentration-time curve (AUC) of tacrolimus was decreased by approximately 20%, peak blood concentration (Cmax) by 16%, and 12-hour blood concentration by 26% when tacrolimus (0.1 mg/kg twice a day) was administered during the tenth day of caspofungin therapy (70 mg/day), as compared to results from a control period in which tacrolimus was administered alone. The mechanism of this potential interaction is unknown. In vitro studies indicate that caspofungin is not an inhibitor of any enzyme in the CYP450 system.

MANAGEMENT: During concomitant therapy, tacrolimus blood levels should be monitored as usual and the dosage adjusted accordingly, particularly following initiation or discontinuation of caspofungin therapy in patients who are stabilized on tacrolimus.

Caspofungin Acetate Injection

Generic Name: caspofungin

Brand name: Cancidas

Synonyms: Caspofungin

What is Caspofungin Acetate Injection?

Envarsus XR

Generic Name: tacrolimus

Brand name: Envarsus XR, Astagraf XL, Prograf, Hecoria

Synonyms: n.a.

What is Envarsus XR?