Castor Oil and Sapropterin Dihydrochloride

• Generic Name: castor oil
• Dosage Forms: n.a.
• Other Brand Names: Chloraseptic, Emulsoil, Neoloid, Purge

Has been used as a stimulant laxative to relieve occasional constipation. However, castor oil usually is avoided for simple constipation because it produces violent purgation.

Use of stimulant laxatives for simple constipation is seldom necessary or desirable.

If a stimulant laxative is used, senna derivatives are preferred.

Stimulant laxatives have been used to treat constipation that occurs following prolonged bed rest or hospitalization.

Stimulant laxatives have been used to treat constipation resulting from diminished colonic motor response in geriatric patients but, because this type of constipation is frequently due to psychological or physical laxative dependence, the bulk-forming laxatives are preferred.

Stimulant laxatives are used to treat constipation occurring secondary to idiopathic slowing of transit time, to constipating drugs, or to irritable bowel or spastic colon syndrome.

Stimulant laxatives have been used to treat constipation in patients with neurologic constipation.

Used orally to empty the bowel prior to surgery or radiologic, proctoscopic, or sigmoidoscopic procedures, when thorough evacuation is essential.

Usually supplemented with administration of rectal evacuants, such as saline, stimulant, or soapsuds enemas, immediately before radiologic procedures.

• Generic Name: sapropterin
• Dosage Forms: n.a.
• Other Brand Names: Kuvan

Used to reduce blood phenylalanine concentrations in patients with hyperphenylalaninemia associated with tetrahydrobiopterin (BH4)-responsive phenylketonuria (PKU). Use in conjunction with a phenylalanine-restricted diet. Designated an orphan drug by FDA for this use.