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Ceenu and Phenobarbital Tablets

Determining the interaction of Ceenu and Phenobarbital Tablets and the possibility of their joint administration.

Check result:

Ceenu <> Phenobarbital Tablets

Relevance: 13.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Animal studies (rats and mice) have shown that pretreatment with phenobarbital significantly reduces the antitumor activity of lomustine. The mechanism may involve a markedly enhanced rate of drug elimination from the plasma, probably as a result of microsomal-enzyme induction by phenobarbital. This interaction has been documented with carmustine, a related nitrosourea. Until further data are available, no specific precautions are recommended.

References

"Product Information. CeeNU (lomustine)." Bristol-Myers Squibb, Princeton, NJ.

Ceenu

Generic Name: lomustine

Brand name: Gleostine, Ceenu

Synonyms: Ceenu (Oral), CeeNU

What is Ceenu?

Phenobarbital Tablets

Generic Name: phenobarbital

Brand name: Solfoton, Luminal

Synonyms: Phenobarbital, PHENobarbital

What is Phenobarbital Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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