Cefditoren pivoxil and Probenecid and colchicine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Like other beta-lactam antibiotics, the coadministration with probenecid may increase the plasma concentrations of cefditoren pivoxil. The mechanism is competitive inhibition by probenecid of the renal tubular secretion of these antibiotics. According to the manufacturer, a single dose of probenecid increased the mean peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and half-life of a single dose of cefditoren pivoxil by 49%, 122% and 53%, respectively. While this interaction may be exploited to enhance the antibacterial effect of cefditoren pivoxil, the potential for toxicity should be considered if the normal dosage of cefditoren pivoxil is administered with probenecid. A reduced dosage of cefditoren pivoxil may be required.

Cefditoren pivoxil

Generic Name: cefditoren

Brand name: Spectracef

Synonyms: Cefditoren

What is Cefditoren pivoxil?

Probenecid and colchicine

Generic Name: colchicine / probenecid

Brand name:

Synonyms: Probenecid and colchicine (Oral)

What is Probenecid and colchicine?