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Cefotan and Rifadin

Determining the interaction of Cefotan and Rifadin and the possibility of their joint administration.

Check result:

Cefotan <> Rifadin

Relevance: 09.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using rifAMPin together with cefoTEtan can cause you to bleed more easily. You may need a dose adjustment in addition to special testing if you use both medications. Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration of rifampin with other antibiotics which cause vitamin K dependent coagulopathy, such as cephalosporins with the N-methyl-thiotetrazole (NMTT) side chain, may increase the risk of severe coagulation disorders, which may result in fatal outcomes (particularly with high doses). The mechanism for this interaction has not been clearly delineated; however, proposed mechanisms include inhibited growth of vitamin K-producing intestinal bacteria, inhibited production of vitamin K-dependent clotting factors, interference with the biosynthesis of prothrombin, and/or inhibited platelet activity. Decreased prothrombin activity has been reported during treatment with rifampin and various cephalosporins. Risk factors may include the elderly, renal or hepatic impairment, poor nutritional state, protracted antimicrobial therapy, and chronic anticoagulation therapy.

MANAGEMENT: The concomitant use of rifampin with other antibiotics which cause vitamin K dependent coagulopathy, such as cephalosporins, should be avoided. If coadministration is unavoidable, monitoring of prothrombin time and INR should be considered and the patient should be observed for signs of bleeding. Patients should be advised to notify their physicians if they experience any signs or symptoms that may indicate excessive anticoagulation, such as unusual or prolonged bleeding, bruising, coffee ground emesis, change in stool or urine color, headache, dizziness, or weakness.

References

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Sieradzan RR, Bottner WA, Fasco MJ, Bertino JS Jr "Comparative effects of cefoxitin and cefotetan on vitamin K metabolism." Antimicrob Agents Chemother 32 (1988): 1446-9
Khaleeli M, Giorgio AJ "Defective platelet function after cephalosporin administration." Blood 48 (1976): 791-2
Agnelli G, Del Favero A, et al "Cephalosporin-Induced Hypoprothrombinemia: Is the N-Methylthiotetrazole Side Chain the Culprit?" Antimicrob Agents Chemother 29 (1986): 1108-1109
Wood T, Johnson K, Naylor S, Weinshilboum R "Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: possible relationship to hypoprothrombinemia." Drug Metab Dispos 30 (2002): 1123-1128
Reddy J, Bailey RR "Vitamin K deficiency developing in patients with renal failure treated with cephalosporin antibiotics." N Z Med J 92 (1980): 378-80
Chen LJ, Hsiao FY, et al "Use of Hypoprothrombinemia-Inducing Cephalosporins and the Risk of Hemorrhagic Events: A Nationwide Nested Case-Control Study." PLoS One 11 (2016): 1-11
Lipsky JJ "N-methyl-thio-tetrazole inhibition of the gamma carboxylation of glutamic acid: possible mechanism for antibiotic-associated hypoprothrombinaemia." Lancet 2 (1983): 192-3
Haubenstock A, Schmidt P, Zazgornik J, et al "Hypoprothrombinaemic bleeding associated with ceftriaxone." Lancet 1 (1983): 1215-6
Natelson EA, Brown CH, 3d Bradshaw MW, Alfrey CP, Jr Williams TW, Jr "Influence of cephalosporin antibiotics on blood coagulation and platelet function." Antimicrob Agents Chemother 9 (1976): 91-3
Shearer MJ, Bechtold H, Andrassy K, Koderisch J, McCarthy PT, Trenk D, Jahnchen E, Ritz E "Mechanism of cephalosporin-induced hypoprothrombinemia: relation to cephalosporin side chain, vitamin K metabolism, and vitamin K status." J Clin Pharmacol 28 (1988): 88-95
Mackie IJ, Walshe K, et al "Effects of N-methyl-thiotetrazole cephalosporin on haemostasis in patients with reduced serum vitamin K1 concentrations." J Clin Pathol 39 (1986): 1245-1249
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Osborne JC "Hypoprothrombinemia and bleeding due to cefoperazone." Ann Intern Med 102 (1985): 721-2
Cerner Multum, Inc. "Australian Product Information." O 0
Parker SW, Baxter J, Beam TR "Cefoperazone-induced coagulopathy." Lancet 1 (1984): 1016
Meisel S "Hypoprothrombinemia due to cefoperazone." Drug Intell Clin Pharm 18 (1984): 316
Lerner PI, Lubin A "Coagulopathy with cefazolin in uremia." N Engl J Med 290 (1974): 1324
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Cefotan

Generic Name: cefotetan

Brand name: Cefotan

Synonyms: n.a.

What is Cefotan?

Rifadin

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rifadin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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