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Cefotetan and Heparin and Sodium Chloride

Determining the interaction of Cefotetan and Heparin and Sodium Chloride and the possibility of their joint administration.

Check result:

Cefotetan <> Heparin and Sodium Chloride

Relevance: 04.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cefoTEtan together with heparin can cause you to bleed more easily. If you are elderly, have kidney problems, or are undernourished you are at a greater risk. You may need a dose adjustment in addition to special testing if you use both medications. Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Cefamandole, cefoperazone, and cefotetan contain a methylthiotetrazole (MTT) side chain that may interfere with the biosynthesis of prothrombin. These agents have rarely been associated with bleeding and with significant increases in prothrombin times. These effects may potentiate the effects of heparin. Patients who are elderly, renally impaired, or undernourished appear to be at a greater risk.

MANAGEMENT: Usually, no special management is necessary, but the patient should be monitored for bleeding if heparin must be given concurrently. Vitamin K is effective in treating cephalosporin-induced coagulopathies.

References

Parker SW, Baxter J, Beam TR "Cefoperazone-induced coagulopathy." Lancet 1 (1984): 1016
Bang NU, Tessler SS, Heidenreich RO, et al "Effects of moxalactam on blood coagulation and platelet function." Rev Infect Dis 4 (1982): s546-54
Meisel S "Hypoprothrombinemia due to cefoperazone." Drug Intell Clin Pharm 18 (1984): 316
Angaran DM, Dias VC, Arom KV, et al "The comparative influence of prophylactic antibiotics on the prothrombin response to warfarin in the postoperative prosthetic cardiac valve patient." Ann Surg 206 (1987): 155-61
Weitekamp MR, Aber RC "Prolonged bleeding times and bleeding diathesis associated with moxalactam administration." JAMA 249 (1983): 69-71
Osborne JC "Hypoprothrombinemia and bleeding due to cefoperazone." Ann Intern Med 102 (1985): 721-2
Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):
Lipsky JJ "N-methyl-thio-tetrazole inhibition of the gamma carboxylation of glutamic acid: possible mechanism for antibiotic-associated hypoprothrombinaemia." Lancet 2 (1983): 192-3
Cristiano P "Hypoprothrombinemia associated with cefoperazone treatment." Drug Intell Clin Pharm 18 (1984): 314-6
Joehl RJ, Rasbach DA, Ballard JO, et al "Moxalactam: evaluation of clinical bleeding in patients with abdominal infection." Arch Surg 118 (1983): 1259-61

Cefotetan

Generic Name: cefotetan

Brand name: Cefotan

Synonyms: CefoTEtan

What is Cefotetan?

Heparin and Sodium Chloride

Generic Name: heparin

Brand name: Hep-Pak, Heparin Lock flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage, HepFlush

Synonyms: Heparin Injection, Heparin

What is Heparin and Sodium Chloride?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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