Cefpodoxime Proxetil Suspension and Proferrin-ES

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using cefpodoxime together with raNITIdine is not recommended. By reducing stomach acid, raNITIdine can decrease the absorption and blood levels of cefpodoxime and make the medication less effective against infections. You may need to stop taking raNITIdine while you are being treated with cefpodoxime, or your doctor may want to prescribe a different antibiotic. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: The coadministration with H2-receptor antagonists, proton pump inhibitors, or other agents that can increase gastric pH may reduce the oral bioavailability of cefpodoxime proxetil and cefuroxime axetil. The proposed mechanism is a pH-dependent reduction in drug dissolution and absorption. In ten healthy volunteers, famotidine 40 mg administered one hour before the ingestion of cefpodoxime proxetil 200 mg led to an approximately 40% reduction in the cefpodoxime peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) compared to when the drug was given alone. Similar results were reported with ranitidine in another study, where cefpodoxime Cmax and AUC decreased by approximately 30%. Likewise, pretreatment with ranitidine plus sodium bicarbonate decreased the Cmax and AUC of cefuroxime by over 40% in six healthy volunteers. The clinical significance of these effects is unknown, but potentially reduced antibiotic efficacy should be considered.

MANAGEMENT: Until further data are available, patients treated with cefpodoxime proxetil or cefuroxime axetil may want to avoid using H2-receptor antagonists, proton pump inhibitors, or other agents that can increase gastric pH. An alternative antibiotic may be considered if these medications cannot be discontinued.

Cefpodoxime Proxetil Suspension

Generic Name: cefpodoxime

Brand name: Vantin

Synonyms: Cefpodoxime

What is Cefpodoxime Proxetil Suspension?

Proferrin-ES

Generic Name: heme iron polypeptide

Brand name: Proferrin-ES, Baciguent, Probiotic Formula

Synonyms: n.a.

What is Proferrin-ES?