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Ceftaroline Fosamil and Plazomicin Intravenous

Determining the interaction of Ceftaroline Fosamil and Plazomicin Intravenous and the possibility of their joint administration.

Check result:

Ceftaroline Fosamil <> Plazomicin Intravenous

Relevance: 01.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Plazomicin can sometimes cause kidney damage, and using it with a cephalosporin antibiotic like ceftaroline may increase that risk. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Signs and symptoms of kidney damage may include nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Let your doctor know if you experience some or all of these problems during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of aminoglycosides and cephalosporins may increase the risk of nephrotoxicity. An increased incidence of nephrotoxicity has been reported during concomitant use of aminoglycosides and some, mostly older cephalosporins (e.g., cefaloridine, cefamandole, cefazolin, cefotaxime, cefoxitin, ceftazidime, cefuroxime, cephalothin, ceftriaxone). The risk may be greatest in the elderly or patients with preexisting renal impairment, when large doses are used, and during prolonged treatment. However, some studies have reported no adverse interaction between certain combinations of these agents.

MANAGEMENT: The lowest effective dosages of aminoglycosides and cephalosporins should be used when they are prescribed in combination. Renal function should be monitored closely. The same precaution may be applicable when aminoglycosides are administered via irrigation, intrapleurally, intraperitoneally or orally, since aminoglycosides can be systemically absorbed via these routes; however, clinical data are lacking.

References

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Ceftaroline Fosamil

Generic Name: ceftaroline

Brand name: Teflaro

Synonyms: Ceftaroline

What is Ceftaroline Fosamil?

Plazomicin Intravenous

Generic Name: plazomicin

Brand name: Zemdri

Synonyms: Plazomicin

What is Plazomicin Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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