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Ceftriaxone and Phenytek

Determining the interaction of Ceftriaxone and Phenytek and the possibility of their joint administration.

Check result:

Ceftriaxone <> Phenytek

Relevance: 06.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Ceftriaxone may displace phenytoin from serum protein-binding sites. Plasma levels of free phenytoin may increase. Some investigators have recommended monitoring of free phenytoin levels in patients who must receive both ceftriaxone and phenytoin.

References

Dasgupta A, Dennen DA, Dean R, McLawhon RW "Displacement of phenytoin from serum protein carriers by antibiotics: studies with ceftriaxone, nafcillin, and sulfamethoxazole." Clin Chem 37 (1991): 98-100

Ceftriaxone

Generic Name: ceftriaxone

Brand name: Rocephin, Rocephin IM Convenience Kit, Rocephin ADD-Vantage

Synonyms: Ceftriaxone (injection), CefTRIAXone

What is Ceftriaxone?

Phenytek

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: n.a.

What is Phenytek?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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