Ceftriaxone and Dextrose and Heparin Lock Flush Solution
Determining the interaction of Ceftriaxone and Dextrose and Heparin Lock Flush Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Ceftriaxone has been associated with an increase in prothrombin time and episodes of bleeding. These effects may potentiate the effects of heparin. Usually, no special management is necessary, but the patient should be monitored for bleeding if ceftriaxone and heparin must be given together. Vitamin K has been successfully used to treat cephalosporin-induced coagulopathies.
- Haubenstock A, Schmidt P, Zazgornik J, et al "Hypoprothrombinaemic bleeding associated with ceftriaxone." Lancet 1 (1983): 1215-6
- Angaran DM, Dias VC, Arom KV, et al "The comparative influence of prophylactic antibiotics on the prothrombin response to warfarin in the postoperative prosthetic cardiac valve patient." Ann Surg 206 (1987): 155-61
Generic Name: ceftriaxone
Brand name: Rocephin, Rocephin IM Convenience Kit, Rocephin ADD-Vantage
Synonyms: Ceftriaxone (injection), CefTRIAXone
Generic Name: heparin
Brand name: Hep-Pak, Heparin Lock flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage, HepFlush
Synonyms: Heparin Injection, Heparin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ceftriaxone and Dextrose-Heparin Sodium
- Ceftriaxone and Dextrose-Heparin, Concentrate
- Ceftriaxone and Dextrose-Hepatamine
- Ceftriaxone and Dextrose-Hepatasol Injection
- Ceftriaxone and Dextrose-Hepatitis A adult vaccine
- Ceftriaxone and Dextrose-Hepatitis A and Hepatitis B Recombinant Vaccine
- Heparin Lock Flush Solution-Ceftriaxone injection
- Heparin Lock Flush Solution-Ceftriaxone Sodium
- Heparin Lock Flush Solution-Cefuroxime
- Heparin Lock Flush Solution-Cefuroxime Axetil
- Heparin Lock Flush Solution-Cefuroxime Axetil Oral Suspension
- Heparin Lock Flush Solution-Cefuroxime Dextrose