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Ceftriaxone injection and Heparin and Dextrose

Determining the interaction of Ceftriaxone injection and Heparin and Dextrose and the possibility of their joint administration.

Check result:

Ceftriaxone injection <> Heparin and Dextrose

Relevance: 02.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Ceftriaxone has been associated with an increase in prothrombin time and episodes of bleeding. These effects may potentiate the effects of heparin. Usually, no special management is necessary, but the patient should be monitored for bleeding if ceftriaxone and heparin must be given together. Vitamin K has been successfully used to treat cephalosporin-induced coagulopathies.

References

Haubenstock A, Schmidt P, Zazgornik J, et al "Hypoprothrombinaemic bleeding associated with ceftriaxone." Lancet 1 (1983): 1215-6
Angaran DM, Dias VC, Arom KV, et al "The comparative influence of prophylactic antibiotics on the prothrombin response to warfarin in the postoperative prosthetic cardiac valve patient." Ann Surg 206 (1987): 155-61

Ceftriaxone injection

Generic Name: ceftriaxone

Brand name: Rocephin, Rocephin IM Convenience Kit, Rocephin ADD-Vantage

Synonyms: Ceftriaxone (injection), CefTRIAXone

What is Ceftriaxone injection?

Heparin and Dextrose

Generic Name: heparin

Brand name: Hep-Pak, Heparin Lock flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage, HepFlush

Synonyms: Heparin Injection, Heparin

What is Heparin and Dextrose?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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