Ceftriaxone injection and Verapamil Hydrochloride PM
Determining the interaction of Ceftriaxone injection and Verapamil Hydrochloride PM and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking cefTRIAXone, tell your doctor if you also use verapamil. You may need dose adjustments or special tests in order to safely take both medications together. Taking these medications together may increase the effects of verapamil. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: According to a single case report, when ceftriaxone and clindamycin were added to the regimen of a patient who was receiving a stable dosage of verapamil and other medications, acute verapamil toxicity resulted. The patient developed complete heart block. The mechanism is unknown and causality was not clearly determined. The purported mechanism (displacement of verapamil from protein binding sites) has been disputed.
MANAGEMENT: Until more information is available, patients should be monitored for verapamil toxicity.
- Kishore K, Raina A, Misra V, Jonas E "Acute verapamil toxicity in a patient with chronic toxicity: possible interaction with ceftriaxone and clindamycin." Ann Pharmacother 27 (1993): 877-80
Generic Name: ceftriaxone
Brand name: Rocephin, Rocephin IM Convenience Kit, Rocephin ADD-Vantage
Synonyms: Ceftriaxone (injection), CefTRIAXone
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ceftriaxone injection-Verapamil Immediate-Release Tablets
- Ceftriaxone injection-Verapamil Injection
- Ceftriaxone injection-Verapamil Intravenous
- Ceftriaxone injection-Verapamil Long-Acting Capsules
- Ceftriaxone injection-Verapamil Long-Acting Tablets
- Ceftriaxone injection-Verapamil oral/injection
- Verapamil Hydrochloride PM-Ceftriaxone Sodium
- Verapamil Hydrochloride PM-Cefuroxime
- Verapamil Hydrochloride PM-Cefuroxime Axetil
- Verapamil Hydrochloride PM-Cefuroxime Axetil Oral Suspension
- Verapamil Hydrochloride PM-Cefuroxime Dextrose
- Verapamil Hydrochloride PM-Cefuroxime Injection