Celecoxib Capsules and Metoprolol Succinate ER Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using metoprolol together with celecoxib can increase your blood levels of metoprolol. This can lower your blood pressure and slow your heart rate, causing side effects such as slow heartbeat, headaches, dizziness, or feeling like you might pass out. Talk with your doctor before using these medications together, and report any side effects promptly. You may need a dose adjustment or need your blood pressure checked more often if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with celecoxib may increase the plasma concentrations of metoprolol. The mechanism is celecoxib inhibition of metoprolol metabolism via CYP450 2D6. In 12 healthy male volunteers, pretreatment with celecoxib (200 mg orally twice daily for 7 days) increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of metoprolol (50 mg single dose) by 38% and 64%, respectively, compared to administration of metoprolol alone. One patient had a 204% increase in metoprolol AUC following celecoxib pretreatment. The magnitude of the interaction was significantly greater in subjects with 2 fully functional alleles associated with CYP450 2D6 activity (i.e., homozygous extensive metabolizers (EMs) of CYP450 2D6) than in subjects with only 1 fully functional allele (i.e., heterozygous EMs). The relative increase in metoprolol AUC by celecoxib was 103% and 36%, respectively, while relative decrease in metoprolol oral clearance by celecoxib was 46% and 25%, respectively, in homozygous EMs versus heterozygous EMs. Poor metabolizers of CYP450 2D6 were excluded from the study.

MANAGEMENT: Although metoprolol has a wide therapeutic range, caution is advised during coadministration with celecoxib because hemodynamic effects of metoprolol may be related to plasma concentration. Patients should be monitored for increased pharmacologic effects that may result in bradycardia or hypotension.

Celecoxib Capsules

Generic Name: celecoxib

Brand name: Celebrex, Celebrex

Synonyms: Celecoxib

What is Celecoxib Capsules?

Metoprolol Succinate ER Tablets

Generic Name: metoprolol

Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL

Synonyms: Metoprolol

What is Metoprolol Succinate ER Tablets?