Celexa (Citalopram Solution) and Orap
Determining the interaction of Celexa (Citalopram Solution) and Orap and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using pimozide together with citalopram is not recommended. Combining these medications can increase the risk of an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with pimozide. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Coadministration with citalopram has been shown to potentiate the effects of pimozide on the QT interval. The mechanism of interaction is unknown. In a controlled study of healthy young adults, administration of pimozide (2 mg single dose) in combination with citalopram (40 mg once daily for 11 days) was associated with a mean increase in QTc values of approximately 10 msec compared to pimozide given alone. The QTc increase occurred in the absence of a clinically significant pharmacokinetic interaction, as pimozide peak plasma concentration (Cmax) and systemic exposure (AUC) were not substantially or consistently altered during citalopram coadministration. Although not reported in the study, excessive prolongation of the QT interval is associated with ventricular arrhythmias such as ventricular tachycardia and torsade de pointes and sudden death.
MANAGEMENT: The use of pimozide in combination with citalopram or escitalopram is considered contraindicated.
- "Product Information. Orap Tablets (pimozide)." Gate Pharmaceuticals, Sellersville, PA.
- Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ([2006]):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Lexapro (escitalopram)." Forest Pharmaceuticals, St. Louis, MO.
- "Product Information. Celexa (citalopram)." Forest Pharmaceuticals, St. Louis, MO.
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Generic Name: citalopram
Brand name: Celexa
Synonyms: Celexa
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Celexa (Citalopram Solution)-Orapred
- Celexa (Citalopram Solution)-Orapred ODT
- Celexa (Citalopram Solution)-Oraqix
- Celexa (Citalopram Solution)-Orasol
- Celexa (Citalopram Solution)-OraVerse
- Celexa (Citalopram Solution)-Oravig
- Orap-Celexa (Citalopram Tablets)
- Orap-Celexib 100- EZS
- Orap-Cellcept
- Orap-CellCept (Mycophenolate Mofetil Capsules)
- Orap-CellCept (Mycophenolate Mofetil Injection Solution)
- Orap-CellCept (Mycophenolate Mofetil Oral Suspension)