Celexa (Citalopram Tablets) and Conivaptan Hydrochloride
Determining the interaction of Celexa (Citalopram Tablets) and Conivaptan Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 3A4 is not expected to significantly affect the pharmacokinetics of citalopram or escitalopram, both of which are partially metabolized by the isoenzyme. Administration of racemic citalopram (40 mg) in combination with the potent CYP450 3A4 inhibitor ketoconazole (200 mg) decreased the ketoconazole peak plasma concentration (Cmax) by 21% and systemic exposure (AUC) by 10%, but did not significantly affect the pharmacokinetics of citalopram. Likewise, coadministration of a single 20 mg dose of escitalopram with a single 600 mg dose of ritonavir, another potent CYP450 3A4 inhibitor, did not affect the pharmacokinetics of either drug. Because citalopram and escitalopram are both metabolized by multiple isoenzymes (CYP450 2C19, 3A4, and 2D6), inhibition of a single isoenzyme may not appreciably decrease their clearance.
- "Product Information. Lexapro (escitalopram)." Forest Pharmaceuticals, St. Louis, MO.
- "Product Information. Celexa (citalopram)." Forest Pharmaceuticals, St. Louis, MO.
Generic Name: citalopram
Brand name: Celexa
Synonyms: Celexa
Generic Name: conivaptan
Brand name: Vaprisol
Synonyms: Conivaptan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Celexa (Citalopram Tablets)-Conivaptan Intravenous
- Celexa (Citalopram Tablets)-Conjugated estrogens
- Celexa (Citalopram Tablets)-Conjugated estrogens and bazedoxifene
- Celexa (Citalopram Tablets)-Conjugated estrogens and medroxyprogesterone
- Celexa (Citalopram Tablets)-Conjugated estrogens and medroxyprogesterone Oral
- Celexa (Citalopram Tablets)-Conjugated Estrogens Injection
- Conivaptan Hydrochloride-Celexib 100- EZS
- Conivaptan Hydrochloride-Cellcept
- Conivaptan Hydrochloride-CellCept (Mycophenolate Mofetil Capsules)
- Conivaptan Hydrochloride-CellCept (Mycophenolate Mofetil Injection Solution)
- Conivaptan Hydrochloride-CellCept (Mycophenolate Mofetil Oral Suspension)
- Conivaptan Hydrochloride-CellCept (Mycophenolate Mofetil Tablets)