CellCept (Mycophenolate Mofetil Oral Suspension) and Cresemba (Isavuconazonium Sulfate Injection)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Isavuconazonium may increase the blood levels and effects of mycophenolate mofetil. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with isavuconazonium sulfate (prodrug of isavuconazole) may increase the bioavailability of mycophenolic acid. The proposed mechanism is isavuconazole inhibition of the UGT-mediated metabolism of mycophenolic acid. When a single 1 gram dose of mycophenolate mofetil was administered to healthy volunteers following multiple dosing of isavuconazonium sulfate, mycophenolic acid systemic exposure (AUC) increased by nearly 40%.

MANAGEMENT: Caution is advised when mycophenolic acid is prescribed with isavuconazonium sulfate. Clinical and laboratory monitoring are recommended following the addition or withdrawal of isavuconazonium sulfate, and the mycophenolic acid dosage adjusted as necessary.

CellCept (Mycophenolate Mofetil Oral Suspension)

Generic Name: mycophenolate mofetil

Brand name: Cellcept, Myfortic, MMF

Synonyms: CellCept

What is CellCept (Mycophenolate Mofetil Oral Suspension)?

Cresemba (Isavuconazonium Sulfate Injection)

Generic Name: isavuconazonium

Brand name: Cresemba

Synonyms: Cresemba

What is Cresemba (Isavuconazonium Sulfate Injection)?