CellCept (Mycophenolate Mofetil Oral Suspension) and Omeprazole and sodium bicarbonate
Determining the interaction of CellCept (Mycophenolate Mofetil Oral Suspension) and Omeprazole and sodium bicarbonate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using mycophenolate mofetil together with omeprazole. Combining these medications may reduce the blood levels of mycophenolate mofetil. Whether this will decrease the effectiveness of mycophenolate mofetil in the treatment of your condition is unknown. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with proton pump inhibitors may reduce the bioavailability of mycophenolic acid (MPA) from the administration of mycophenolate mofetil. The exact mechanism of interaction has not been established, but may involve a decrease in MPA solubility at higher gastric pH levels. When single doses of proton pump inhibitors were given to healthy volunteers and multiple doses to transplant patients receiving mycophenolate mofetil, MPA peak plasma concentration (Cmax) was reduced by 30% to 70% and systemic exposure (AUC) by 25% to 35%. The clinical significance is unknown. The interaction does not appear to occur when mycophenolic acid itself is administered. In 12 healthy volunteers, the pharmacokinetics of MPA were observed to be similar when a single 720 mg dose of mycophenolic acid was administered alone and following concomitant administration with pantoprazole, which was administered at a dosage of 40 mg twice daily for 4 days.
MANAGEMENT: Because clinical relevance of this interaction has not been established, proton pump inhibitors should be used with caution in transplant patients receiving mycophenolate mofetil.
- "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories, Nutley, NJ.
- "Product Information. Myfortic (mycophenolic acid)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: mycophenolate mofetil
Brand name: Cellcept, Myfortic, MMF
Synonyms: CellCept
Generic Name: omeprazole / sodium bicarbonate
Brand name: Zegerid, Zegerid OTC
Synonyms: Omeprazole and Sodium Bicarbonate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- CellCept (Mycophenolate Mofetil Oral Suspension)-Omeprazole and Sodium Bicarbonate Capsule
- CellCept (Mycophenolate Mofetil Oral Suspension)-Omeprazole and Sodium Bicarbonate Capsules
- CellCept (Mycophenolate Mofetil Oral Suspension)-Omeprazole and Sodium Bicarbonate Powder Packets
- CellCept (Mycophenolate Mofetil Oral Suspension)-Omeprazole Delayed-Release Capsules
- CellCept (Mycophenolate Mofetil Oral Suspension)-Omeprazole Delayed-Release Capsules and Tablets (OTC)
- CellCept (Mycophenolate Mofetil Oral Suspension)-Omeprazole Orally-Disintegrating Tablets
- Omeprazole and sodium bicarbonate-CellCept (Mycophenolate Mofetil Tablets)
- Omeprazole and sodium bicarbonate-Cellcept Oral
- Omeprazole and sodium bicarbonate-Celontin
- Omeprazole and sodium bicarbonate-Celontin Kapseals
- Omeprazole and sodium bicarbonate-Cemill
- Omeprazole and sodium bicarbonate-Cemill 1000