CellCept (Mycophenolate Mofetil Oral Suspension) and Valcyte

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using valGANciclovir together with mycophenolate mofetil may increase the blood levels of one or both medications. You may be at increased risk for side effects, particularly if you have kidney disease. Combining these medications may also have additive effects on bone marrow function, resulting in low numbers of different types of blood cells. You may be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if you develop paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Data from a single-dose study do not suggest the potential for a clinically significant pharmacokinetic interaction between mycophenolic acid and ganciclovir in patients with normal renal function. However, since ganciclovir and the glucuronide metabolite of mycophenolic acid are both eliminated primarily by the kidney, plasma levels of both may increase in renal impairment due to competition for renal tubular secretion. In addition, use of mycophenolic acid and ganciclovir may increase the risk and severity of hematologic toxicity due to additive myelosuppressive effects.

MANAGEMENT: Caution is advised if ganciclovir or its prodrug, valganciclovir, must be used concomitantly with mycophenolic acid products in patients with impaired renal function. Close monitoring for toxicities such as myelo- and immunosuppression is recommended.

CellCept (Mycophenolate Mofetil Oral Suspension)

Generic Name: mycophenolate mofetil

Brand name: Cellcept, Myfortic, MMF

Synonyms: CellCept

What is CellCept (Mycophenolate Mofetil Oral Suspension)?

Valcyte

Generic Name: valganciclovir

Brand name: Valcyte

Synonyms: n.a.

What is Valcyte?